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phenobarbital will lessen the level or effect of buprenorphine, extensive-acting injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. People who transfer to buprenorphine lengthy-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers must be monitored to be sure bupreno